Ocular and cardiovascular response to topical carteolol 2% and timolol 0.5% in healthy volunteers.
نویسندگان
چکیده
Ocular and cardiovascular effects of carteolol 2%, timolol 0.5%, and dummy eyedrops have been measured in a single dose double-blind crossover study in six healthy volunteers. Both drugs lowered intraocular pressure and reduced exercise-induced tachycardia. Neither produced a significant change in resting heart rate or blood pressure. The two agents appear comparable as regards ocular hypotensive and cardiovascular effects.
منابع مشابه
Topical beta-blockade with intrinsic sympathomimetic activity offers no advantage for the respiratory and cardiovascular function of elderly people.
Topical therapy with beta-antagonists, such as timolol, may cause unrecognized impairment of respiratory and cardiovascular function in elderly people. Beta-antagonists with intrinsic sympathomimetic or cardioselective properties, such as carteolol or betaxolol, may cause less impairment. In a randomized, double-masked study of glaucoma patients, over 60 years of age, without history of broncho...
متن کاملThe 12-hour control of intraocular pressure on carteolol 2% twice daily.
In a 15-week double-blind, placebo-controlled, crossover study both carteolol 2% and timolol 0.5% produced a significant reduction in intraocular pressure. Twelve hours after administration the reduction in pressure on carteolol was significantly less than that obtained on timolol.
متن کاملمقایسه تاثیر تیمولول و بتاکسولول بر کاهش فشار داخل چشمی و عوارض موضعی و سیستمیک آنها
Background and purpose: This is a study to compare the efficacy and side effects of betaxolol and timolol in lowering the IOP of primary open angle glaucoma or ocular hypertension. Materials and Methods: This Double-blind randomized cross-over clinical trial was conducted on 29 eyes of 20 patients with primary open angle glaucoma or ocular hypertension. Each patient received timolol 0.5% a...
متن کاملTopical ophthalmic beta blockers may cause release of histamine through cytotoxic effects on inflammatory cells.
AIM To evaluate the effects of beta blockers used in ophthalmology on the release of histamine from mixed cell preparations containing human leucocytes and basophils. METHODS A mixed leucocyte and basophil preparation was obtained from venous blood of healthy non-atopic volunteers. Cell preparations were then incubated with betaxolol, metipranolol, timolol, or carteolol. After incubation for ...
متن کاملContact allergic dermatitis and contact urticaria due to topical ophthalmic preparations.
A patient with chronic glaucoma and a history of contact allergic dermatitis to topical ophthalmic , adrenergic blocking drugs developed persistent ocular symptoms despite avoidance of , blockers. He was further investigated for possible allergy to pilocarpine. Case report A 70-year-old man presented with a persistent itch involving his eyes and a stinging and burning sensation aggravated by in...
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ورودعنوان ژورنال:
- The British journal of ophthalmology
دوره 72 2 شماره
صفحات -
تاریخ انتشار 1988